Anti-Pressure Pills are rather large, oval shaped pills created by Professor Hubert J. Farnsworth. The pills allow users to survive in high-pressure environments.
The pill is a suppository according to a conversation between Philip J. Fry I and Professor Farnsworth. It is not user-friendly due to its size as equal to a goose egg.
Later when the Planet Express crew was going into the depths of the ocean the Professor continually asked them if they had taken their suppository. Amy Wong screamed "YES!! stop asking"