The Applied Cryogenics was a place in Manhattan, Old New York in the late 20th century and early 21st century.

The Applied Cryogenics building in 1999

Both Fry and Michelle were cryogenically frozen at Applied Cryogenics. Pauly Shore was also frozen there.

Before quitting to work at Planet Express, Leela worked there as a fate assignment officer. When they were briefly fired, Fry and Bender also worked at Applied Cryogenics for a time. Fry actually caused himself to be frozen in the first place after he was sent back in time to stop Nibbler from doing the same thing in the original timeline.

Various future versions of Bender and Fry caused by repeated use of the Time Sphere hid in the cryogenics lab and Bender, with his self-destruct system activated, was frozen on January 1, 2000. This played an important part in the climactic scene of "Bender's Big Score". Additionally, Lars Fillmore, a parallel-past version of Fry, was also frozen there some time later, hiding in the same tube Michelle was in. He supposedly emerged soon after Michelle did in the Cryonic Woman. In the audio commentary for Bender's Big Score, it is joked about how many people are hiding around the room.

In a What-If Machine vision where Fry was never frozen, Applied Cryogenics was the starting point of a universe-wide implosion.

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