The whole episode is a reference to sports athletes and doping abuse. It could be a reference to the fact that many female athletes had strongly abused doping over the years, to the point of becoming masculine, having gotten deeper voices and more masculine features.
The Butterfly Effect
The name of the episode, "The Butterjunk Effect", is a reference to the 2004 American science fiction psychological thriller, The Butterfly Effect. They both reference the scientific term.
Trivia
The name of the arena is Monsanto Yokel Dome. In "The Series Has Landed", the Goophy Gophers Revue is presented by the Monsanto corporation.
